Dry eye disease(DED)
Conditions
Interventions
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-70 years old, gender not limited, able to understand and sign informed consent forms; 2.Dry Eye group (DED) : according to TFOS Dews III (2025) diagnostic criteria: (symptom positivity: Osdi-6 score =4 points (or OSDI =13 points) ; and with at least one of the following signs of loss of homeostasis: non-invasive tear film rupture time (NIBUT) 8 mOsm/L) or positive ocular surface staining (corneal fluorescein staining > 5 points or conjunctival risperidone green staining > 9 points or palpebral margin staining length =2 mm and width =25%) ; 3.Healthy control group (Control): no eye discomfort symptoms (OSDI-6 <4 points or OSDI <13 points); normal eye surface steady-state indicators (NIBUT = 10 seconds, no eye surface staining, normal tear osmotic pressure); no eye disease history and surgical history; 4.Non-dry eye ocular surface disease control group (Other): Non-dry eye ocular surface disease clinically diagnosed by slit lamp microscopy. For patients with "co-disease" who may also have dry eye signs (e.g. NIBUT < 10s), clinical judgment of the investigator must be made at the time of enrollment to confirm that the main driving factor of their ocular complaints and signs is the above "other ocular surface disease".
Exclusion criteria
Exclusion criteria: 1.High-risk infectious eye disease: in the acute phase of bacterial, viral (such as adenovirus conjunctivitis) , fungal keratitis or conjunctivitis patients; 2.Severe ocular surface damage: corneal fluorescein staining (CFS) score> 3, or presence of corneal ulcers, perforations and other lesions that may seriously interfere with tear components; 3.History of eye surgery (e.g. cataract, refractive surgery) or eye trauma in recent 3 months; 4.Have worn contact lenses (contact lenses) within the last 1 month; 5.Within the past month, the following drugs have been used in the eyes and throughout the body: antibiotics, glucocorticoid drugs, immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, eye soaps and acaricides. 6.Artificial tears were used on the day of the examination; 7.Have a systemic disorder that severely affects tear production (such as uncontrolled diabetes, Sjögren's syndrome) ; 8.Pregnant or lactating women; 9.Insufficient tear samples (< 10 ?L) for follow-up testing; 10.The investigator considers that the sample does not meet the test requirements and the investigator considers that it is not suitable to participate in the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear Metabolites;Tear Functional Proteins;Tear Inflammatory Factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| OSDI Score;CFS Grade;NIBUT;Schirmer I Test Value; | — |
Countries
China
Contacts
Public ContactQi Dai
Eye Hospital, Wenzhou Medical University
Outcome results
None listed