Pain after shoulder joint surgery
Conditions
Interventions
Liposomal bupivacaine + bupivacaine hydrochloride group:133mg of liposomal bupivacaine (10mL) +25mg of bupivacaine hydrochloride (5mL
concentration 0.5%), the total volume after mixing is 15mL.Perform intermuscular groove brachial plexus block
The bupivacaine hydrochloride group was used alone:75mg of bupivacaine hydrochloride, with a total volume of 15mL and a concentration of 0.5%.Perform intermuscular groove brachial plexus block
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ASA classification I to III; 2. 18 years old or above; 3. Plan to undergo elective major shoulder surgery (rotator cuff repair or total shoulder replacement).
Exclusion criteria
Exclusion criteria: 1. Allergic or intolerant to amide local anesthetics; 2. There is objective evidence of nerve injury in the affected upper limb; 3. Mental or cognitive impairments that may affect perioperative assessment; 4. Recent (<3 months) history of drug or alcohol abuse; 5. There is already a coagulation dysfunction; 6. Receive opioid drug treatment simultaneously; 7. Had undergone surgery on the contralateral shoulder joint within 12 months prior to randomization; 8. Participated in another research trial involving the investigational drug product within 6 months prior to randomization; 9. Infection at the injection site; 10. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score;Postoperative inflammatory factors (IL-1, IL-6, IL-10, TNF);NRS rating; | — |
Countries
China
Contacts
Public ContactXintao Wang
Shanghai Sixth People's Hospital
Outcome results
None listed