Sepsis
Conditions
Interventions
Xuebijing group:100mL of Xuebijing Injection and 100mL of 0.9% sodium chloride Injection are diluted and administered intravenously twice a day for a course of 7 days
Control group:100mL of 0.9% sodium chloride injection (the same as the appearance placebo) was intravenously infused twice a day for a course of 7 days
Sponsors
Ningbo Zhenhai District Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Meet the diagnostic criteria of sepsis 3.0; 3. No AGI occurred at the time of enrollment (AGI grade 0; 4. The estimated length of stay in the ICU is >=72 hours; 5. The patient or his/her legal representative signs a written informed.
Exclusion criteria
Exclusion criteria: 1. The primary infection site is located in the gastrointestinal tract. 2. There was a history of chronic gastrointestinal failure or major gastrointestinal surgery before enrollment; 3. Known to be allergic to the components of Xuebijing Injection; 4. Pregnancy or lactation period; 5. Severe underlying diseases such as advanced malignant tumors that may interfere with endpoint assessment; 6. Participate in other interventional clinical trials simultaneously; 7. Any level of AGI already existed at the time of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of AGI (grade >= I); | — |
Secondary
| Measure | Time frame |
|---|---|
| The time until AGI occurs;28-day all-cause mortality rate;Length of stay in the ICU and total length of stay;SOFA score and APACHE II score;Duration of mechanical ventilation;inflammatory markers;Feeding tolerance indicators; | — |
Countries
China
Contacts
Public ContactLi Fang
Ningbo Zhenhai District Hospital of Traditional Chinese Medicine
Outcome results
None listed