Studies on the Functional Changes of Human Thymic and Peripheral T Cells during Aging

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600122780

Enrollment

Unknown

Registered

2026-04-17

Start date

2025-10-21

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

Youth (12-30 years old) group:None

middle-aged and elderly (30-60 years old) group:None

elderly (over 60 years old) group:None

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Undergoing cardiac orthopedic surgery; 2. Having no other known diseases; 3. For patients undergoing total thymectomy or partial thymectomy during the operation, the resection ratio of patients with partial thymectomy is calculated based on preoperative and postoperative chest CT imaging data. 4. Included age groups: young people (12-30 years old), middle-aged and elderly people (30-60 years old), and elderly people (over 60 years old). In each age group, 3 patients with total thymectomy and 3 patients with partial thymectomy are included (with consistent gender).

Exclusion criteria

Exclusion criteria: Smokers, those with a history of cancer, those with chronic inflammatory diseases (arthritis, Crohn's disease, colitis, dermatitis, fibromyalgia, and lupus), HIV infection, hepatitis B, hepatitis C, and autoimmune diseases, among others.

Design outcomes

Primary

Measure	Time frame
Differences in gene expression of immune cells in the thymus among different age groups;The number of RTEs in peripheral blood in different age groups;Differences in gene expression of immune cells in peripheral blood among different age groups;Differences in gene expression of chromatin accessibility in the thymus among different age groups;Differences in immune repertoires of immune cells in peripheral blood among different age groups;Differences in gene expression of immune repertoires in the thymus among different age groups;Differences in chromatin accessibility of immune cells in peripheral blood among different age groups;T cell function in peripheral blood in different age groups;	—

Measure

Time frame

Differences in gene expression of immune cells in the thymus among different age groups;The number of RTEs in peripheral blood in different age groups;Differences in gene expression of immune cells in peripheral blood among different age groups;Differences in gene expression of chromatin accessibility in the thymus among different age groups;Differences in immune repertoires of immune cells in peripheral blood among different age groups;Differences in gene expression of immune repertoires in the thymus among different age groups;Differences in chromatin accessibility of immune cells in peripheral blood among different age groups;T cell function in peripheral blood in different age groups;

—

Secondary

Measure	Time frame
Copy numbers of sjTRECs in peripheral blood of different age groups;	—

Countries

China

Contacts

Public ContactWang Xiaowen

The First Affiliated Hospital of Chongqing Medical University

xiaowenwang@yeah.net+86 23 89011010

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026