Postoperative delirium
Conditions
Interventions
POD Group:None
Non-POD Group:None
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective thoracic surgery; 2. Age >=18 years old; 3. ASA Class I-III; 4. NYHA Class I-II.
Exclusion criteria
Exclusion criteria: 1. Accompanied by severe liver and kidney dysfunction; 2. Accompanied by respiratory failure; 3. Severe mental illness, recently taken sedatives or antidepressants; 4. Strict attention to hearing impairment or severe disability without self-care ability; 5. Severe cerebrovascular diseases such as intracranial aneurysms, severe stenosis or occlusion of head and neck arteries, vascular cognitive impairment, a history of intracranial hemorrhage with sequelae or brain trauma; 6. Preoperative coma, severe dementia, or speech disorder and unable to cooperate with the study; 7. Preoperative MMSE score <24 points; 8. Those who have participated in other clinical trials or refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microRNA30a;Post-operative delirium assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum S100ß protein;Neuron-specific enolase, NSE;Tumor Necrosis Factor-alpha, TNF-a;Interleukin-6,IL-6;General observation indicators: gender, age, BMI, ASA classification, NYHA classification, MMSE score, past medical history, blood routine, coagulation function, cardiac function and liver and kidney function, etc; | — |
Countries
China
Contacts
Public ContactWu Yuli
Tianjin First Central Hospital
Outcome results
None listed