Inflammatory bowel disease,IBD
Conditions
Interventions
Inflammatory bowel disease group,:None
Sponsors
Yuebei People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inflammatory Bowel Disease 1. Age: Usually 18-65 years old. 2. Diagnosis: Patients with IBD who meet the diagnostic criteria of the Chinese Medical Association's Society of Gastroenterology, Inflammatory Bowel Disease Group, the Chinese Crohn's Disease Diagnosis and Treatment Guidelines (2023, Guangzhou), or the Chinese Ulcerative Colitis Diagnosis and Treatment Guidelines (2023, Xi'an), confirmed by clinical, endoscopic, imaging, and pathological examinations, including Crohn's disease and ulcerative colitis. Informed consent: Patients must voluntarily participate and sign an informed consent form. Healthy Population 1. Age: Usually 18-65 years old. 2. No abnormalities in blood routine, urine routine, liver function, kidney function, blood glucose, blood lipids, chest X-ray, ECG, ultrasound, and other indicators during physical examination at our hospital's health examination center. Research subjects must sign an informed consent form to confirm their voluntary participation in the study.
Exclusion criteria
Exclusion criteria: Inflammatory Bowel Disease 1. Combined with other digestive system diseases: such as viral hepatitis, cirrhosis, biliary obstruction, and other diseases that affect bile acid metabolism. 2. Combined with severe systemic diseases: such as heart, liver, kidney dysfunction, malignant tumors, etc. 3. Recent medication use: recent use of drugs that affect bile acid metabolism, such as bile acid chelating agents, antibiotics, etc. 4. Pregnant or breastfeeding women: hormone changes may affect bile acid metabolism. 5. Mental illness or inability to cooperate: patients unable to cooperate to complete the study. Other situations that do not meet study requirements: such as recent surgery, severe infection, etc. Healthy Population 1. Acute disease symptoms such as acute infection, fever, vomiting, diarrhea within 1 month prior to the study. 2. Major surgery or hospitalization within 3 months prior to the study. 3. Use of drugs that may affect study results (such as immunosuppressants, hormones, etc.) within 1 month prior to the study. 4. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bile acid metabolism; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease activity indices (CDAI, Mayo score);inflammatory markers (CRP, ESR, fecal calprotectin);endoscopic scores (SES-CD, UCEIS); | — |
Countries
China
Contacts
Public ContactRao Peisi
Yuebei People’s Hospital
Outcome results
None listed