general anesthesia induction of elderly patients
Conditions
Interventions
Remimazolam group:Anesthesia induction was performed with remimazolam at a dose of 0.2~0.3 mg/kg, administered by intravenous bolus injection within 1 minute.
Propofol group:Anesthesia induction was performed with propofol at a dose of 1~2 mg/kg, administered by intravenous bolus injection within 1 minute.
Fospropofol disodium group:Anesthesia induction was performed with fospropofol disodium at a dose of 10~12 mg/kg, administered by intravenous bolus injection within 1 minute.
Sponsors
The First People’s Hospital of Jingzhou
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 60 years, gender not limited, with American Society of Anesthesiologists (ASA) physical status classification of grade ? to ?. 2. Body mass index (BMI) ranged from 18.5 to 30 kg/m²; 3. Scheduled for elective general anesthesia with the expected duration of surgery more than 30 minutes. 4. Clear consciousness before surgery and able to cooperate with the completion of basic assessments. 5. Patients and their family members provided informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Scheduled to undergo cardiac surgery, craniocerebral surgery, burn surgery or interventional surgery. 2. A history of severe heart, brain, lung, liver, kidney and metabolic diseases. 3. Unable to receive bispectral index (BIS) monitoring. 4. A history of allergy to general anesthetics such as remimazolam and propofol; 5. Patients with difficult airway. 6. Patients with uncontrolled hypertension and diabetes mellitus. 7. Currently participating in another interventional study. 8. Suspected of abusing narcotic analgesics or sedatives. 9. Pregnant or lactating women. 10. Patients with neuromuscular system diseases or mental illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during anesthesia induction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes during anesthesia induction;Duration of anesthetic intubation;Duration of successful anesthesia induction;Adverse reactions; | — |
Countries
China
Contacts
Public ContactLi Tang
The First People’s Hospital of Jingzhou
Outcome results
None listed