None
Conditions
Interventions
Experimental group:Two minutes before anesthesia induction, the initial dose of norepinephrine was pumped at 0.03 µg/(kg·min).
Control group:Two minutes before anesthesia induction, normal saline was pumped in (calculated based on the dose of norepinephrine).
Sponsors
The First Medical Center of the PLA General Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 60 - 80 years old, 18.5 kg/m^2 <= BMI <= 28 kg/m^2, has received preoperative chemotherapy; 2. Planned to undergo elective general anesthesia surgery; 3. ASA score: II-III grade; 4. The patient agrees to participate in the clinical study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Has a history of severe cardiovascular diseases (such as congestive heart failure, severe angina pectoris attacks, and myocardial infarction within the past 6 months); 2. Renal dysfunction, renal failure; 3. Patients with severe microcirculation disorders: patients with occlusive vasculitis, thrombotic diseases; 4. History of norepinephrine allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure - Actual Variability; | — |
Secondary
| Measure | Time frame |
|---|---|
| The area under the curve and the time for the average arterial pressure to be <= 65 mmHg within 30 minutes of induction;The area under the curve for MAP less than or equal to 60 mmHg;The area under the curve for MAP less than or equal to 50 mmHg;The area under the curve for MAP less than or equal to 40 mmHg;The area under the curve for MAP values greater than or equal to 100 mmHg;The area under the curve for MAP values greater than or equal to 110 mmHg;The area under the curve for MAP values greater than or equal to 120 mmHg;The area under the curve for MAP values greater than or equal to 140 mmHg;The cumulative dosage of norepinephrine; | — |
Countries
China
Contacts
Public ContactZhang Changsheng
The First Medical Center of the PLA General Hospital
Outcome results
None listed