lung cancer, pulmonary sarcoidosis, infectious pulmonary nodules, pulmonary tuberculosis, pneumoconiosis nodules, etc
Conditions
Interventions
matched historical cohort group:forceps biopsy
intervention group:Transbronchial pulmonary cryobiopsy
Sponsors
Chui Yang Liu Hospital affiliated to Tsinghua University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Thin-section CT indicates peripheral solitary pulmonary nodules (diameter < 30mm), with negative results from conventional bronchoscopy (without navigation/ultrasound guidance); 2.The patient or their legal representative has signed the informed consent form; 3.The expected survival period is more than 6 months, and the patient can cooperate with the 6-month follow-up.
Exclusion criteria
Exclusion criteria: 1.Intolerance to intravenous anesthesia or bronchoscopic procedures (e.g., severe cardiopulmonary insufficiency); 2.severe arrhythmia (e.g., uncontrolled ventricular tachycardia); 3.Coagulation disorders (INR > 1.5 or platelets 100 ml within 24 hours); 4.Nodules adjacent to large blood vessels (distance < 5 mm) or pleura (distance < 2 mm), with extremely high biopsy risk evaluated by multidisciplinary consultation (MDC); 5.Complicated with severe infection, immunodeficiency, or advanced malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| diagnostic rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biopsy time(minutes);The proportion of specimens adequate for genetic testing;Percentage of specimens =2mm in diameter;bleeding;pneumothorax;subgroup diagnostic rate; | — |
Countries
China
Contacts
Public ContactChen Xing
Chui Yang Liu Hospital affiliated to Tsinghua University
Outcome results
None listed