Uterine fibroids and adenomyosis
Conditions
Interventions
Intrathecal Placebo + Standard Postoperative Care:Intrathecal Placebo
Intrathecal Morphine + Standard Postoperative Care:intrathecal morphine
Sponsors
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.adult patients aged 18 to 60 years who were able to provide informed consent; American Society of Anesthesiologists (ASA) physical status I or II; 2.a diagnosis of uterine fibroids or adenomyosis scheduled for elective unilateral or bilateral uterine artery embolization; 3.body mass index (BMI) between 18 and 35 kg/m²;
Exclusion criteria
Exclusion criteria: 1.known allergy to local anesthetics, opioids, or nonsteroidal anti-inflammatory drugs; 2.cognitive or language impairment precluding participation in the study or completion of questionnaires; 3.refusal to undergo the planned procedure for any reason prior to surgery; 4.preexisting neurological disorders; 5.contraindications to neuraxial anesthesia, including infection at or near the injection site or coagulopathy (defined as an international normalized ratio >1.3 and/or a platelet count <100 × 10?/L); 6.prior opioid use before surgery; 7.and preoperative pain with a numerical rating scale (NRS) score greater than 3;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15(24 hours after surgery); | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption;patient satisfaction;time to first patient-controlled analgesia (PCA) demand;number of patient-controlled analgesia (PCA) demands;Quality of Recovery-15(2 days after surgery);Inflammatory markers;Postoperative adverse events;Numeric Rating Scale;Surgeon satisfaction; | — |
Countries
China
Contacts
Public ContactZhang Hui
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Outcome results
None listed