None
Conditions
Interventions
Experimental group:According to the modified Dixon sequential method, the dose of tegileridine for laryngeal mask airway insertion during propofol induction was determined. The first patient received
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade I-II; 2. Age 18-65 years old; 3. Body mass index 18-30 kg/m^2; 4. Male and female patients requiring propofol-induced endotracheal intubation for general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this study; 2. Unable to cooperate or communicate in Chinese; 3. Participate in other clinical studies; 4. Currently taking any painkillers; 5. Abuse of opioid drugs; 6. Suffering from diseases such as heart, brain, liver, and kidney disorders; 7. for laryngeal mask insertion due to full stomach, facial deformity, or difficulty in opening the mouth; 8. Hypertension, tachycardia, etc., with unstable hemodynamics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Laryngeal mask airway insertion response score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The highest values of MAP and HR and the lowest values of SPO2 were observed during the induction period after tegiladine injection;The incidence of hypertension, hypotension, bradycardia, tachycardia, and hypoxemia (SpO? < 90%) during the induction period after tegileridine injection.;The use of ephedrine and atropine during the induction period.;The requirement for additional propofol during the induction period.;The Ramsay Sedation Score of patients at 3 minutes after tegileridine injection.;Number of laryngeal mask airway insertion attempts;Conversion to general anesthesia with endotracheal intubation;Incidence of pain during propofol injection;Incidence of propofol injection pain;BIS latency, defined as the time interval from patient awakening to the decrease of BIS to 60 after tegileridine injection.;Incidence of adverse reactions (including coughing during induction, muscle rigidity, muscle tremors, limb movement, hiccups, allergic reactions, dizziness, etc.).;Patient baseline characteristics; | — |
Countries
China
Contacts
Public ContactZhang Jingyu
Lanzhou University Second Hospital
Outcome results
None listed