Post-operative nausea and vomit
Conditions
Interventions
Experimental group:The induction protocol employed was propofol 0.4mg/kg (combined with esketamine 0.3mg/kg and lidocaine 1mg/kg)
Control group:The induction protocol employed was propofol 0.4mg/kg + sufentanil 0.3ug/kg + normal saline (the volume being equivalent to lidocaine in the opioid-free group).
Sponsors
Women’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification: Grade I-II; 2. Age: 18 - 60 years old; 3. Planned for elective day surgery with hysteroscopy.
Exclusion criteria
Exclusion criteria: 1. Those with abnormal liver and kidney functions; 2. With a known history of allergy to sedatives or opioids; 3. With a history of alcohol dependence or drug abuse; 4. With morbid obesity (BMI >= 40 kg/m^2); 5. With obstructive sleep apnea syndrome (OSAS); 6. With a history of postoperative nausea and vomiting (PONV); 7. With a history of vertigo.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence rate of PONV within 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Need for rescue anti emetics;Severity of PONV;Pain intensity at rest and while coughing; | — |
Countries
China
Contacts
Public ContactSun Lihong
Women’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed