Sepsis
Conditions
Interventions
Observation group:None
Sponsors
The Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Meet the Sepsis-3 international consensus diagnostic criteria; 3. The time from ICU admission to screening = 8), and at the same time, meeting at least 2 of the following systemic vascular dysfunction-related clinical indicators: serum albumin = 0.1 µg/kg/min to maintain mean arterial pressure >= 65 mmHg for >= 2 hours; lactate >= 2 mmol/L.
Exclusion criteria
Exclusion criteria: 1. Cardiogenic shock or acute decompensated heart failure as the main reason for hospital admission; 2. End-stage kidney disease (baseline eGFR < 15 mL/min/1.73m^2) and long-term dependence on dialysis; 3. Severe liver failure (Child-Pugh class C), active major bleeding; 4. Terminal malignant tumors; 5. ECMO support; 6. Pregnancy; 7. Death within 24 hours after ICU admission or a do-not-resuscitate order has been issued; 8. LUS not completed within 24 hours after ICU admission; 9. Unable to obtain reliable, continuous fluid intake and output records from the time of ICU admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasoactive-Inotropic Score;ICU length of stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vasoactive agent-free days within 28 days;Ventilator-free days within 28 days;Incidence or progression of acute kidney injury (AKI) within the first 7 days of ICU admission;28-day all-cause mortality; | — |
Countries
China
Contacts
Public ContactTian Baoping
The Second Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed