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Mechanism of Neuroinflammation in Cognitive Dysfunction of Critically Ill Patients Based on OrexinA/NF-?B Pathway

Mechanism of Neuroinflammation in Cognitive Dysfunction of Critically Ill Patients Based on OrexinA/NF-?B Pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122676
Enrollment
Unknown
Registered
2026-04-16
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis-Associated Encephalopathy

Interventions

General Infection Group:None
Sepsis Group:None
Septic Shock Group:None

Sponsors

Xiaogan Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Select patients aged 18-65 who have been diagnosed with sepsis due to respiratory, digestive, or urinary system diseases

Exclusion criteria

Exclusion criteria: 1. Patients with anemia, pregnancy, intracranial infection, symptoms of high fever poisoning, various metabolic encephalopathies (hepatic encephalopathy, uremic encephalopathy, pulmonary encephalopathy), history of psychiatric disorders, history of cerebrovascular disease, or cognitive impairment present before enrollment

Design outcomes

Primary

MeasureTime frame
Mini-Mental State Examination Score;Montreal Cognitive Assessment Score;—

Countries

China

Contacts

Public ContactShen Wei

Xiaogan Hospital Affiliated to Wuhan University of Science and Technology

xgsw123@outlook.com+86 151 7125 9720

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026