None listed
Conditions
Interventions
Bupivacaine liposomal group:Bilateral ultrasound-guided anterior quadratus lumborum blocks at the lateral supra-arcuate ligament (QLB-LSAL) were performed postoperatively, with 20 ml (133 mg) of lipos
Standard bupivacaine group:Bilateral ultrasound-guided anterior quadratus lumborum blocks at the lateral supra-arcuate ligament (QLB-LSAL) were performed postoperatively, with 20 ml ( 50 mg) of standa
Sponsors
Mindong Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective cesarean section; 2. Singleton pregnancy with gestational age greater than 37 weeks; 3. American Society of Anesthesiologists (ASA) physical status classification of II; 4. Body mass index (BMI) >= 20 and <= 35 kg/m²; 5. Normal laboratory indicators for liver function, kidney function, and coagulation; 6. Ability to cooperate well with postoperative rest and activity VAS scoring; able to correctly use the intravenous patient-controlled analgesia (PCA) pump under nurse guidance; 7. Detailed understanding of the nature, significance, and potential benefits of the trial, willing to comply with the clinical trial protocol, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with combined psychiatric disorders or cognitive dysfunctions who are unable to cooperate for pain assessment; 2. Severe cardiovascular and cerebrovascular diseases, such as unstable angina, severe arrhythmias, severe valvular heart disease, cerebral infarction, etc.; 3. Patients with liver or kidney dysfunction, coagulation disorders, or blood system infections; 4. Known allergies to bupivacaine or other amide local anesthetics; 5. Patients with diabetic peripheral neuropathy; 6. Infection or tumor lesions at the puncture site; 7. Presence of severe spinal deformities; 8. Other factors deemed inappropriate for participation in the trial by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve (AUC) of cumulative morphine consumption during the first 72 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total opioid consumption within 6h, 12h, 24h, 48h, and 72h after surgery;Visual Analog Scale (VAS) pain scores for rest, movement (coughing), and uterine contractions at 6h, 12h, 24h, 48h, and 72h post-surgery;Time to first use of patient-controlled intravenous analgesia (PCIA) pump post-surgery;Number of patients requiring analgesic rescue;QoR-15 (Quality of Recovery 15) scale scores at 24h, 48h, and 72h post-surgery;Time to first ambulation post-surgery;Time to first passage of gas post-surgery;Time to first lactation post-surgery;Occurrence of chronic pain at 3 months post-surgery;Adverse events within 72 hours post-surgery;Neonatal Behavioral Neurological Assessment (NBNA) at 72 hours post-surgery;Surgery duration;Age;Height;Weight; | — |
Countries
China
Contacts
Public ContactHuang Qingqing
Mindong Hospital Affiliated to Fujian Medical University
Outcome results
None listed