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Mechanobiological mechanisms of the regulation of CD8+T cell immune function by cyclic mechanical stretch in coordination with matrix stiffness via Piezo1 in lung cancer liver metastasis

Mechanobiological mechanisms of the regulation of CD8+T cell immune function by cyclic mechanical stretch in coordination with matrix stiffness via Piezo1 in lung cancer liver metastasis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122666
Enrollment
Unknown
Registered
2026-04-16
Start date
2025-12-01
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Observation group:None

Sponsors

Xi'an Jiaotong University Second Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Aged 18 years or older, regardless of gender; 2.Primary non-small cell lung cancer with clear cytopathological/tissue pathological evidence; 3.Presence of lung cancer liver metastasis with available tissue samples; 4.First-time receipt of anti-tumor immunotherapy, with at least one efficacy evaluation conducted during the treatment period; 5.Consent to participate in the study;

Exclusion criteria

Exclusion criteria: 1.Unknown histopathological type; 2.Refusal to participate in the study; 3.Records of anti-tumor treatment are missing, or participation in blinded drug clinical trials results in unknown medication information; 4.Complicated with other malignant tumors that have not been radically resected; 5.Previous receipt of other immunotherapies except immune checkpoint inhibitors;

Design outcomes

Primary

MeasureTime frame
Tumor Immuno-Physical Characteristics;

Secondary

MeasureTime frame
Overall Survival (OS);Objective Response Rate (ORR);

Countries

China

Contacts

Public ContactGuo Hui

Xi'an Jiaotong University Second Affiliated Hospital

guohuihappy97@163.com+86 13572824106

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026