None
Conditions
Interventions
Remimazolam group:Anesthesia induction with Remimazolam Tosilate (0.2-0.3 mg/kg, intravenous injection) and maintenance by continuous infusion (at a rate of 0.2-3.0 mg/kg/h), combined with Sufentanil
Propofol group:Anesthesia induction with Propofol (1.5-2.5 mg/kg, intravenous injection) and maintenance by continuous infusion (at a rate of 2-5 mg/kg/h), combined with Sufentanil and Cisatracurium (
Sponsors
Shaoxing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18-65 years; 2. American Society of Anesthesiologists (ASA) classification I-III; 3. Planned elective surgery, with an expected duration of 1-6 hours; 4. Patients and their families have signed informed consent and voluntarily agree to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Individuals allergic to benzodiazepines; 2. Those with severe liver or kidney dysfunction (e.g., serum alanine aminotransferase or aspartate aminotransferase exceeding three times the upper limit of normal, creatinine clearance below 50 ml/min); 3. Those with severe cardiovascular diseases (e.g., unstable angina, acute myocardial infarction, severe arrhythmia, NYHA class III or higher heart failure); 4. Those with mental illness or cognitive dysfunction who cannot cooperate with the researchers; 5. Those who have recently (within 3 months) used drugs affecting the central nervous system, such as antidepressants, antiepileptics, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative nausea and vomiting (PONV); | — |
Secondary
| Measure | Time frame |
|---|---|
| perioperative adverse reactions;Hepatic and renal function indices (including Alanine Aminotransaminase [ALT], Aspartate Aminotransaminase [AST], Total Bilirubin [TBIL], Direct Bilirubin [DBIL], Creatinine [Cr], and Blood Urea Nitrogen [BUN]);Coagulation profile (including Prothrombin Time [PT], Activated Partial Thromboplastin Time [APTT], Fibrinogen [FIB], and Platelet Count [PLT]);time to loss of eyelash reflex;BIS values at various time points after drug administration;intraoperative movement response;extubation time;PACU length of stay;VAS score (after extubation);Patient satisfaction with sedation score (1-5 points);Surgeon’s satisfaction with sedation score (1-5 points);perioperative vital signs;QOR-15 score on postoperative day 1;perioperative medication administration; | — |
Countries
China
Contacts
Public ContactZhonghua Chen
Shaoxing People's Hospital
Outcome results
None listed