Research on the Effectiveness and Mechanism of Digital Cognitive Training in Improving MCI Based on EEG and fNIRS

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122653

Enrollment

Unknown

Registered

2026-04-16

Start date

2026-04-17

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment (MCI) refers to a condition characterized by impairment in one or more cognitive domains that does not affect instrumental activities of daily living (IADL) or activities of daily living (ADL).

Interventions

Trial Group:Routine drug therapy, physical therapy, occupational therapy, etc. + once daily 30-minute digital cognitive training for one month + once daily 30-minute traditional occupational therapy c

Control Group:Routine drug therapy, physical therapy, occupational therapy, etc. + twice daily 30-minute traditional occupational therapy cognitive training for one month

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosed with MCI; 2. Aged 18-70; 3. MoCA score 19-25; 4. Expected to be able to independently complete game training and pass the first level of the game; 5. The subject and/or their guardian can understand the purpose of the experiment, show sufficient compliance with the experimental protocol, and sign the informed consent form; 6. The researcher believes that they can participate in this clinical trial.

Exclusion criteria

Exclusion criteria: 1. Without a confirmed diagnosis of mental retardation or other conditions expected to render the subject unable to perform device operations. 2. Absence of unstable brain disease; 3. There is no blindness, hearing impairment, or speech difficulties

Design outcomes

Primary

Measure	Time frame
Change in MoCA Score;LOTCA Cognitive Assessment;Accuracy Rate in Go/No-Go Task;Reaction Time in Go/No-Go Task;Hit Rate in Go/No-Go Task;Accuracy Rate in n-back Task;Reaction Time in n-back Task;Hit Rate in n-back Task;P300 Amplitude in Prefrontal and Parietal ERP;P300 Latency in Prefrontal and Parietal ERP;Cerebral Blood Flow in Prefrontal and Parietal Regions;	—

Secondary

Measure	Time frame
Safety Outcomes (including dizziness, headache, dry eyes, etc.);	—

Countries

China

Contacts

Public ContactDu Xiaoxia

China Rehabilitation Research Center (Beijing Boai Hospital)

364906784@qq.com+86 10 87569850

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026