pain
Conditions
Interventions
tRNS treatment group:A 3-day pain intervention on the contralateral M1, with daily sessions of 20 minutes. Stimulation pattern: tRNS + DC-offset, current intensity: 1 mA tRNS + 1 mA DC-offset.
tDCS treatment group:A 3-day pain intervention on the contralateral M1, with daily sessions of 20 minutes. Stimulation pattern: anodal tDCS, current intensity: 1 mA.
Sponsors
Shenzhen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18–75 years; 2.Pain Duration: Pain persists or recurs for more than 3 months; 3.Pain Location: Pain in clearly localized superficial areas of the trunk or limbs (e.g., neck, shoulder, back, waist, knee, etc.); 4.Pain Intensity: Pain intensity at screening and enrollment, as measured by the Numeric Rating Scale (NRS), scores =30/100; 5.Cognitive Ability and Compliance: Sufficient cognitive ability to understand the study content, voluntarily sign the informed consent form, and commit to complying with the study protocol.
Exclusion criteria
Exclusion criteria: 1. Pain with special etiologies: Pain with clearly defined specific causes, including but not limited to: (1) Cancer pain. (2) Visceral-origin pain. 2. Significant comorbid diseases: (1) History of neurological diseases (such as epilepsy, sequelae of stroke, Parkinson's disease, multiple sclerosis, etc.). (2) History of psychiatric disorders (such as major depressive episodes, bipolar disorder, schizophrenia, etc.). (3) Major organ diseases involving the heart, lungs, liver, kidneys, etc. 3. Recent interventions that may affect efficacy evaluation or safety: (1) Receiving other invasive or non-invasive neuromodulation treatments (such as tDCS, transcranial magnetic stimulation, spinal cord stimulation, etc.) within the past month. (2) Undergoing surgery or major invasive treatment for pain within the past month. (3) Presence of intracranial metal implants, cardiac pacemakers, or other contraindications to transcranial electrical stimulation. 4. Other exclusion criteria: (1) Women who are pregnant or breastfeeding. (2) History of alcohol or drug abuse/dependence. (3) Any other conditions that, in the investigator's judgment, may affect participation in the study or the reliability of data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity;Pain unpleasantness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain sensitivity trait;Conditioned pain modulation;Temporal summation of pain;fMRI resting-state brain activity; | — |
Countries
China
Contacts
Public ContactXiaoyun Li
Shenzhen University
Outcome results
None listed