polycystic ovary syndrome
Conditions
Interventions
Intervention group:Prebiotic-rich diet plan
Control group:Regular diet plan for patients with PCOS
Sponsors
The Sixth Affiliated Hospital of Sun Yat-sen University, Western Guangdong Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Female individuals aged 18 - 40; 2.Meets the Rotterdam PCOS diagnostic criteria (satisfying at least 2 out of the following 3 items: (1) Infrequent ovulation or no ovulation; (2) Clinical and/or biochemical hyperandrogenism; (3) Ultrasound showing polycystic ovarian changes and excluding other causes); 3.Within the past 3 months, has not taken probiotics/probiotics supplements, antibiotics, hormonal drugs (including oral contraceptives, glucocorticoids, etc.), metformin, carbamazepine and other antiepileptic drugs; 4.Voluntarily participates and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Combined diabetes (type 1 or type 2), Cushing's syndrome, congenital adrenal hyperplasia, hyperprolactinemia, abnormal thyroid function; 2.Diagnosis or suspected malignant tumor; 3.Diagnosis of epilepsy or mental psychological disorders; 4.Gastrointestinal disease history (such as inflammatory bowel disease, irritable bowel syndrome, chronic diarrhea), history of gastrointestinal surgery; 5.Pregnant or lactating; 6.Severe heart, liver, or kidney dysfunction; 7.Participating in other clinical trials; 8.Known to be allergic or intolerant to the recommended foods in the study (such as onions, garlic, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HOMA-IR;Free androgen index;oral glucose tolerance release test;Four lipid profile items(TC, TG, HDL-C, LDL-C);totol testosterone;follicle-stimulating hormone;luteinizing hormone;estrogen;progesterone;prolactin;sex hormone binding globulin;thyroid stimulating hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| modified Ferriman-Gallwey hairiness score;height;weight;body mass index;waist hip ratio;blood pressure;Severity grading of acne;16S rRNA sequencing of fecal samples;proinflammatory cytokine;Anti-inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactHui Li
The Sixth Affiliated Hospital of Sun Yat-sen University, Western Guangdong Hospital / Xinyi People's Hospital
Outcome results
None listed