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A Prospective Multicenter Cohort Study on Thulium Fiber Laser versus Holmium Laser in Retrograde Intrarenal Surgery Combined with a Flexible Negative-Pressure Access Sheath for 1–3 cm Upper Urinary Tract Stones

A Prospective Multicenter Cohort Study on Thulium Fiber Laser versus Holmium Laser in Retrograde Intrarenal Surgery Combined with a Flexible Negative-Pressure Access Sheath for 1–3 cm Upper Urinary Tract Stones

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122644
Enrollment
Unknown
Registered
2026-04-16
Start date
2026-05-01
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

urinary stones

Interventions

Thulium fiber laser lithotripsy:none
Holmium laser lithotripsy:none

Sponsors

Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18–75 years; 2. Unilateral upper urinary tract stone confirmed by computed tomography (CT), with a cumulative stone diameter of 1–3 cm on CT; 3. Met the indications for RIRS; 4. Able to comply with the study protocol and complete study-related procedures; 5. Willing to participate in the study and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Congenital or structural renal abnormalities, including horseshoe kidney, medullary sponge kidney, polycystic kidney, and ectopic kidney; 2. History of previous reconstructive surgery of the ipsilateral upper urinary tract; 3. Uncontrolled urinary tract infection; 4. Severe hydronephrosis (RPD > 2 cm); 5. Absolute contraindications to RIRS due to medical or other reasons; 6. Pregnancy.

Design outcomes

Primary

MeasureTime frame
Immediate postoperative stone free rate;

Secondary

MeasureTime frame
Final stone-free rate;Surgical time;Laser activation time;Intraoperative complications;Elevated blood creatinine values 1-2 days postoperatively;Decreased haemoglobin values 1-2 days after surgery;Elevated PCT values 1-2 days after surgery;Elevated WBC values 1-2 days postoperatively;Days of hospitalisation;

Countries

China

Contacts

Public ContactLi Jianxing

Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital

ljxa01048@btch.edu.cn+86 133 2116 9366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026