After cardiopulmonary bypass surgery, complications such as vasoplegia and acute kidney injury may occur.
Conditions
Interventions
Study Group (oXiris Membrane):None
Control group (regular membrane):None
Sponsors
Zhongda Hospital affiliated to Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients are over 18 years old and up to 75 years old; 2.Undergo cardiac surgery with extracorporeal circulation, with extracorporeal circulation time exceeding 90 minutes; 3.Diagnosed with post-CPB vasoplegia within 6 hours after surgery; 4.Have postoperative renal injury and meet the indications for CRRT (Continuous Renal Replacement Therapy).
Exclusion criteria
Exclusion criteria: 1.Patients who have experienced an allergic reaction to the study device (oXiris membrane or M100 membrane); 2.Pregnant or lactating patients; 3.Patients estimated to die within 48 hours; 4.Patients undergoing ECMO (Extracorporeal Membrane Oxygenation); 5.Patients or their immediate relatives refuse to provide written informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasoactive inotropic score, VIS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily demand for vasopressors;Time to shock reversal;Changes in biomarkers;Mechanical ventilation time;ICU non-ventilation time;ICU stay time;Total hospital stay time;ICU mortality rate;In-hospital mortality rate; | — |
Countries
China
Contacts
Public ContactXu Jingyuan
Zhongda Hospital affiliated to Southeast University
Outcome results
None listed