Cough and swallowing disorders after Parkinson's disease
Conditions
Interventions
Experimental group :Conventional swallowing function training,rTMS,Extracorporeal diaphragmatic pacemaker treatment
Control group :Conventional swallowing function training,Extracorporeal diaphragmatic pacemaker treatment
Sponsors
Beijing Haidian Hospital
Eligibility
Sex/Gender
All
Age
38 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age 38-85 years old; 2.All met the diagnostic criteria for primary Parkinson's disease formulated by the Parkinson's Disease and Movement Disorders Group of the Neurology Branch of the Chinese Medical Association in 2016, and were diagnosed after differential diagnosis by CT or MRI, with Hoehn Yahr stage 2-4; 3.Swallowing disorders are confirmed by FESS examination; 4.Cough dysfunction assessed by cough function assessment; 5.All subjects signed a written informed consent form;
Exclusion criteria
Exclusion criteria: 1. History of using sedatives, antidepressants, or other drugs that may alter cortical excitability; 2. Intracranial metal implants, pacemaker, skull defects, history of epilepsy, or other contraindications unsuitable for transcranial magnetic stimulation treatment; 3. Chronic respiratory diseases or history of such diseases (e.g., chronic obstructive pulmonary disease, asthma, emphysema); 4. History of upper respiratory tract infection within the past 4 weeks; 5. Unstable patient condition, presence of contraindications to rehabilitation training.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough reflex threshold;Peak Expiratory Flow Rate,PEFR;Rosenbek penetration aspiration scale, PAS;; | — |
Secondary
| Measure | Time frame |
|---|---|
| Swallowing-specific Quality of Life Scale (SWAL-QOL);Functional near-infrared spectroscopy imaging data analysis; | — |
Countries
China
Contacts
Public ContactDong Xiaojin
Beijing Haidian Hospital
Outcome results
None listed