Bile duct stones
Conditions
Interventions
Omega-3 Fatty Acid Soft Capsule Group:Omega-3 Fatty Acid Intervention Group
Combination Group (Omega-3 Fatty Acids + UDCA):Combined Intervention
UDCA Standard Group:UDCA Standard Group
Placebo Control Group:Placebo (High-Oleic Sunflower Oil) Capsule)
Sponsors
The Second Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 80 years; 2.Diagnosis of biliary stones confirmed by imaging (e.g., ultrasound, CT, MRCP); 3.Planned for surgical intervention with postoperative T-tube placement and confirmed adequate biliary drainage;
Exclusion criteria
Exclusion criteria: 1.History of allergy to Omega-3 or ursodeoxycholic acid (UDCA); 2.Red blood cell Omega-3 index = 8%; 3.Use of UDCA, Omega-3, or similar supplements within the past 3 months; 4.Long-term use of corticosteroids, immunosuppressants, or lipid-lowering agents; 5.Coagulation disorders or bleeding diathesis; 6.Long-term use of anticoagulant or antiplatelet medications; 7.Pregnancy or lactation; 8.Hepatic or renal insufficiency; 9.Presence of severe comorbidities (e.g., cancer, end-stage renal disease, heart failure NYHA class III-IV);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Bile;CompositionChanges in Bile Cholesterol Saturation Index (CSI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory Markers;Adverse Events;Hepatic Function Parameters; | — |
Countries
China
Contacts
Public ContactMiao, Huilai
The Second Affiliated Hospital of Guangdong Medical University
Outcome results
None listed