Renal Protective Effects and Impact on Prognosis of Remote Ischemic Preconditioning in Elderly Patients Undergoing Coronary Artery Bypass Grafting: A Multicenter Randomized Clinical Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122614

Enrollment

Unknown

Registered

2026-04-15

Start date

2026-04-15

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury(AKI)

Interventions

Control Group (C Group):Sham Ischemic Preconditioning Group

Remote Ischemic Preconditioning Group (R Group):Remote Ischemic Preconditioning Group

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=65 years; 2.Scheduled to undergo coronary artery bypass grafting under general anesthesia (with or without cardiopulmonary bypass); 3.Willing to participate in the study and able to complete the full postoperative follow-up.

Exclusion criteria

Exclusion criteria: 1.End-stage renal disease (eGFR 133 µmol/L). 2.History of acute kidney injury (AKI) or status post renal transplantation. 3.History of cardiogenic shock or cardiac arrest during current hospitalization. 4.Acute coronary syndrome within 4 weeks prior to surgery. 5.Any condition that may elevate preoperative cardiac troponin levels (e.g., percutaneous coronary intervention performed within 6 weeks prior to surgery). 6.Requirement for concomitant valve replacement surgery or history of cardiac valve replacement. 7.Peripheral arterial disease affecting the upper extremities, including but not limited to Raynaud's syndrome. 8.Significant hepatic impairment (bilirubin >20 mmol/L, INR <2.0). 9.Severe pulmonary disease (FEV1 <40% of predicted value).

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative acute kidney injury (AKI);	—

Secondary

Measure	Time frame
Perioperative Myocardial Injury (PMI);Total Length of Hospital Stay;Duration of Mechanical Ventilation;Serum Creatinine Concentration;Length of Intensive Care Unit Stay (ICU Length of Stay);All-Cause Mortality or Rehospitalization Rate within 90 Days Postoperatively;Quality of Recovery-15 Score (QoR-15 Score) Postoperatively;Rate of Requirement for Renal Replacement Therapy (RRT) during Hospitalization;Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) within 6 months postoperatively;	—

Measure

Time frame

Perioperative Myocardial Injury (PMI);Total Length of Hospital Stay;Duration of Mechanical Ventilation;Serum Creatinine Concentration;Length of Intensive Care Unit Stay (ICU Length of Stay);All-Cause Mortality or Rehospitalization Rate within 90 Days Postoperatively;Quality of Recovery-15 Score (QoR-15 Score) Postoperatively;Rate of Requirement for Renal Replacement Therapy (RRT) during Hospitalization;Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) within 6 months postoperatively;

—

Countries

China

Contacts

Public ContactSu Liu

The Affiliated Hospital of Xuzhou Medical University

150040009@gmail.com+86 516 85805911

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026