VEGFR1+ CAFs Induced by Cervical Cancer Cells Driving Lymph Node Metastasis via the NRXN3/CLSTN1 Axis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600122599

Enrollment

Unknown

Registered

2026-04-15

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cervical cancer

Interventions

Observational group:None

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.Inclusion criteria included patients with pathologically confirmed cervical cancer, those with complete clinicopathological data (including prognosis, staging, and metastasis status), and patients who voluntarily provided tissue samples and signed informed consent forms.

Exclusion criteria

Exclusion criteria: 1.Exclusion criteria included patients with concurrent other malignant tumors or those whose tissue samples failed to meet the experimental requirements (e.g., severe necrosis).

Design outcomes

Primary

Measure	Time frame
Expression level of VEGFR1+ CAF-specific genes;Distribution and quantity of VEGFR1+ CAF subpopulations in tissues;Migration and invasion ability of cervical cancer cells;Expression level of EMT-related marker molecules;Spatial proximity between VEGFR1+ CAFs and tumor cells;	—

Countries

China

Contacts

Public ContactZhang Shibo

Sun Yat-sen University Cancer Center (Sun Yat-sen University Cancer Hospital, Sun Yat-sen University Cancer Institute)

zhangsb1@sysucc.org.cn+86 20 39336805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026