Senile osteoporosis
Conditions
Interventions
Old-age Osteoporosis Group:None
Postmenopausal Osteoporosis Group:None
Old-age Non-osteoporosis Group:None
Postmenopausal Non-osteoporosis Group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily agree to participate in this study and sign the written informed consent form; 2. Age >= 18 years; 3. Gender: No gender restrictions. 4. Diagnosed as osteoporotic or non-osteoporotic according to the Guidelines for the Diagnosis and Treatment of Primary Osteoporosis (2022 Edition) and the WHO bone mineral density diagnostic criteria; 5. Scheduled to undergo spine-related surgery such as discectomy or decompressive laminectomy based on the attending physician's clinical judgment;
Exclusion criteria
Exclusion criteria: 1. Presence of endocrine or metabolic diseases affecting bone metabolism (e.g., parathyroid dysfunction, diabetes mellitus, hyperthyroidism or hypothyroidism, etc.); 2. Long-term use of medications that affect bone metabolism, such as glucocorticoids, antiepileptics, or immunosuppressants; 3. Prior systematic treatment with anti-osteoporosis drugs (e.g., bisphosphonates, denosumab, etc.); 4. Presence of severe infection, malignant tumor, or active inflammatory disease; 5. Any other condition that, in the investigator's judgment, makes the subject unsuitable for participation in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression differences and functional mechanisms of oxidative stress-related genes and metabolites in different subtypes of osteoporosis;Differential expression of oxidative stress-related genes in peripheral blood and bone tissue;Impact of oxidative stress-related genes and metabolites on bone mineral density and bone quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between serum metabolites (e.g., TC, HDL, UA, vitamin B6, vitamin E) and risk of osteoporosis development;Differences in oxidative stress levels and gene expression between different subtypes of osteoporosis (PMOP vs. SOP);Interaction between oxidative stress-related genes and metabolites and their impact on bone metabolism; | — |
Countries
China
Contacts
Public ContactZhu Siyuan
Southern Medical University Southern Hospital
Outcome results
None listed