Type 2 diabetes
Conditions
Interventions
Combine at least one diabetic microvascular complication:None
Sponsors
General Hospital of the Western Theater Command of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Common inclusion criteria (both groups must meet): (1)Age > 60 years; (2)Underlying disease: meeting the WHO 2023 diagnostic criteria for diabetes; (3) Disease duration = 5 years (to ensure sufficient duration for the development of complications); (4) HbA1c fluctuation within 6.5-9.0 in the past 3 months (to control the interference of extremely high blood glucose); (5)Voluntary participation and signing of the informed consent form. 2. Experimental group (microvascular complications group): Complicated with at least one diabetic microvascular complication: (1) Diabetic nephropathy (proteinuria (UACR = 30 mg/g) for 2 consecutive times or eGFR < 60 ml/min/1.73m², excluding other nephropathies); (2) Diabetic retinopathy (ETDRS stage = non-proliferative stage, with clear diagnosis by fundus angiography/OCT). 3. Specific criteria for the control group (no complications group): All must be met: (1) Normal urinary albumin excretion (UACR < 30 mg/g); (2) Fundus examination excludes signs of diabetic retinopathy, including macular edema, macular hemorrhage, microaneurysms, etc.; (3)Age matched with the experimental group.
Exclusion criteria
Exclusion criteria: 1.Acute or chronic infection, with peripheral blood high-sensitivity C-reactive protein > 10mg/L; 2. History of malignant tumors; 3. Autoimmune diseases; 4. History of major surgery/blood transfusion within 3 months; 5.Use of immunosuppressants/biologics; 6.Type 1 diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CXC motifligand 14, CXCL14;Fasting blood glucose;glycated hemoglobin;C-peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood lipids;Renal function;Liver function;Urinalysis;Urinary microalbumin to creatinine ratio;Fundus condition; | — |
Countries
China
Contacts
Public ContactKe Yu
General Hospital of the Western Theater Command of the Chinese People's Liberation Army
Outcome results
None listed