None listed
Conditions
Interventions
Test group 1:0.3325% liposomal bupivacaine injection with a total volume of 25 mL was administered for ultrasound-guided serratus anterior plane block (SAPB).
Control group:Ultrasound-guided serratus anterior plane block (SAPB) was performed using a 0.5% ropivacaine mixed solution containing 4 mg dexamethasone at a total volume of 25 mL.
Sponsors
Lishui People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients of either sex, aged 18 to 65 years, with a body mass index (BMI) ranging from 20 to 30 kg/m²; 2. American Society of Anesthesiologists (ASA) physical status classification Grade ? or ?; 3. Patients scheduled for elective uniportal video-assisted thoracoscopic lobectomy; 4. Patients who have signed the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to the local anesthetics used in this study (bupivacaine, ropivacaine); 2. Regular opioid use within the past 3 months or a history of substance abuse; 3. A history of chronic pain requiring long-term medication; 4. A history of previous ipsilateral thoracic surgery or trauma; 5. Intolerance to non-steroidal anti-inflammatory drugs (NSAIDs), active gastric ulcer, abnormal coagulation function, or severe hepatic or renal insufficiency; 6. Severe cardio-cerebrovascular diseases, uncontrolled hypertension, epilepsy, psychiatric disorders, pregnancy or lactation; 7. Communication disorders, cognitive dysfunction, or any other condition that renders the patient unable to cooperate with pain scale assessments and study follow-up; 8. Emergency surgery, intraoperative conversion to thoracotomy, or the presence of contraindications to serratus anterior plane block (SAPB) (e.g., infection at the puncture site, patient refusal).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine milligram equivalents of opioid consumption postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption;Numeric Rating Scale (NRS) pain scores at rest ;Time to first PCA pump activation;Postoperative quality of recovery (15-item Quality of Recovery Scale, QoR-15);Incidence of adverse events (AEs);Incidence of chronic pain at 3 months postoperatively;NRS score on movement (during deep breathing);Rescue analgesic consumption;Postoperative length of hospital stay;Time to first postoperative ambulation;Incidence of postoperative pulmonary complications;Mean arterial pressure;Heart rate; | — |
Countries
China
Contacts
Public ContactDong Xiaoli
Lishui People's Hospital, Lishui, Zhejiang 323000, China
Outcome results
None listed