Analgesic effect and neuroplasticity mechanism of accelerated theta burst stimulation in chronic post-stroke shoulder pain

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122536

Enrollment

Unknown

Registered

2026-04-15

Start date

2026-04-15

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-stroke shoulder pain

Interventions

aiTBS intervention group:The intra-frequency is set at 50Hz, with an intra-count of 3, and the inter-frequency at 5Hz. The stimulation lasts for 2 seconds, with an 8-second interval, repeated 20 times

Conventional 10Hz therapy group:The stimulation parameters for the first trial are as follows: a 10Hz stimulation sequence lasting for 5 seconds each, with an interval of 25 seconds between sequences,

Control group:Treatment was administered using a pseudo-stimulation coil (Magstim, P/N 3950-00) that only emitted sound without applying a real pulse. Other treatment parameters were consistent with t

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meets the diagnostic criteria for chronic post-stroke shoulder pain established by the International Association for the Study of Pain; 2. Unilateral brain injury caused by stroke or hemorrhage; 3. Average VAS pain score > 30 mm over the past week; 4. Age 18 years or older; 5. Disease duration of more than 3 months; 6. No history of shoulder pain prior to the stroke; 7. No history of peripheral neuropathy in the upper limb prior to the stroke;

Exclusion criteria

Exclusion criteria: 1. Contraindications for transcranial magnetic stimulation (TMS) treatment (e.g., presence of implanted electronic devices or metal in the body); 2. Severe mental illness, aphasia, or cognitive impairment (Mini-Mental State Examination score <=24); 3. Suicidal ideation or behavior; 4. History of seizures or family history of epilepsy; 5. Unstable medical condition or concurrent severe cardiovascular, pulmonary, hepatic, or renal disease; 6. Complete paralysis of the limb on the side to be stimulated; 7. Pregnant or breastfeeding women; 8. History of substance abuse (alcohol, drugs); 9. Patients with severe fear of TMS treatment or who are unable to cooperate with the procedure;

Design outcomes

Primary

Measure	Time frame
Transcranial Magnetic Stimulation Evoked Potentials,TEP;	—

Secondary

Measure	Time frame
Transcranial Magnetic Stimulation Evoked oscillation,TE0;	—

Countries

China

Contacts

Public Contactzhao ying

Jinhua Hospital of Traditional Chinese Medicine

zhaoying_015@163.com+86 136 4679 2016

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026