Moyamoya Disease
Conditions
Interventions
Normobaric Hyperoxia Group:From intraoperative period (after anesthesia induction) to 4 hours postoperatively, patients inhaled 100% oxygen via a non?rebreathing mask at a flow rate of 10 L/min
for intubated patients, the fraction of inspired oxygen (FiO?) was set at 1.0.
Sham Control Group:Within the same time period, patients received low?flow oxygen at 1 L/min through identical?appearance masks
for intubated patients, FiO? was set at 0.3. The mask valves were kept open to mimic the sound of high?flow oxygen delivery.
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 65 years; 2. Diagnosis of moyamoya disease (Suzuki Stage I–IV) confirmed by digital subtraction angiography (DSA) or magnetic resonance angiography (MRA); 3.Scheduled to receive combined cerebral revascularization surgery; 4. Preoperative modified Rankin Scale (mRS) score = 1; 5. Voluntary participation in this study with signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of severe cardiac, pulmonary, hepatic or renal insufficiency (e.g., chronic obstructive pulmonary disease, heart failure); 2.Requiring continuous high-flow oxygen therapy (>3 L/min) preoperatively to maintain SpO2 > 94%; 3. Complicated with active pulmonary infection or acute respiratory distress syndrome (ARDS); 4. Pregnant or breastfeeding women; 5. Expected survival duration < 90 days; 6. Any other conditions deemed unsuitable for participation in this study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS Scale; | — |
Countries
China
Contacts
Public ContactLiming Zhao
Henan Provincial People's Hospital
Outcome results
None listed