helicobacter pylori infection
Conditions
Interventions
vonoprazan combined with amoxicillin dual therapy:vonoprazan 20mg twice daily, Amoxicillin 1000mg three times daily, for a 14-day duration.
vonoprazan 20mg twice daily, Tetracycline 500mg three times daily, for a 14-day duration:vonoprazan 20mg twice daily, Tetracycline 500mg three times daily, for a 14-day duration
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-75 years; 2. Confirmed positive for H. pylori infection by 13C/14C-urea breath test or pathological diagnosis (if using 13C-UBT, the cutoff value must be above 6, and if using 14C-UBT, the value must be more than twice the critical value to be included); 3. Undergoing initial H. pylori eradication therapy.
Exclusion criteria
Exclusion criteria: 1. Allergic to the study drug; 2.Use of PPIs in the past 2 weeks or antibiotics or bismuth in the past 4 weeks; 3.History of gastric surgery; 4. Severe comorbid conditions; 5.Pregnant or breastfeeding women; 6. Refusal to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate of helicobacter pylori; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of adverse effect; | — |
Countries
China
Contacts
Public ContactYouhua Wang
The first affiliated hostipal of nanchang university
Outcome results
None listed