Postoperative inflammatory response
Conditions
Interventions
TXA Group:Intravenous infusion of tranexamic acid 1.5g 30 min before surgery (diluted to 100 ml normal saline 0.9%, completed within 15 min)
no NSAIDs allowed during perioperative period and study observation period
KET Group:Intravenous infusion of ketorolac tromethamine 30 mg 30 min before surgery (diluted to 100 ml normal saline 0.9%, completed within 15 min)
no tranexamic acid or similar agents allowed during perioperative period and study observation period
Sponsors
The First Hospital Of Jiaxing
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Elderly patients aged >=65 years, regardless of gender, with ASA grades I to III who are scheduled for unilateral knee arthroscopic surgery under general anesthesia
Exclusion criteria
Exclusion criteria: 1.People allergic to tranexamic acid or NSAIDs; 2.Those with concurrent cardiovascular or cerebrovascular diseases; 3.Those with abnormal blood coagulation function; 4.Those with severely abnormal liver and kidney functions; 5.Those with a history of deep vein thrombosis or pulmonary embolism; 6.People who have been using hormone drugs or NSAIDs for a long time; 7.Patients who are unable to cooperate to complete the assessment; 8.Those who have recently undergone heavy manual surgery; 9.Refuse to participate in this researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The serum IL-6 level of postoperative patients;Postoperative serum C-reactive protein level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;He occurrence of adverse reactions;Postoperative venous blood biochemical indicators; | — |
Countries
China
Contacts
Public ContactDeng Kang
The First Hospital Of Jiaxing
Outcome results
None listed