Liver cirrhosis ( LC ) is the final pathological change of liver injury caused by various chronic liver diseases. It is also the main cause of high morbidity and mortality worldwide. About 1 million people die of liver cirrhosis every year worldwide. Cirrhosis is the 11th most common cause of death in the world and the third leading cause of death for people aged 45-64. The disease evolves from as
Conditions
Interventions
Compensatory cirrhosis group:None
Decompensated cirrhosis group:None
Recompensation cirrhosis group:None
Sponsors
Shenzhen Hospital of Southern Medical Unversity
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Compensatory cirrhosis group : 1. Age : >= 30 and <= 70 years old, gender unlimited ; 2. all patients with liver cirrhosis were diagnosed according to the international liver disease standards, including imaging, clinical symptoms, laboratory tests or liver biopsy, past medical history and complications of liver cirrhosis. 3. Agree to participate in this study, and have signed the informed consent. Decompensated cirrhosis group : 1. Patients with clear causes of liver cirrhosis (hepatitis B, hepatitis C, alcoholic liver cirrhosis) aged between 30 and 70 years old, regardless of gender; 2. All patients with liver cirrhosis are diagnosed according to international liver disease standards, including: imaging, clinical symptoms, laboratory tests or liver biopsy, past medical history and complications of liver cirrhosis; 3. Complications of liver cirrhosis (such as ascites, gastrointestinal bleeding, hepatic encephalopathy (overt), hepatorenal syndrome, etc.) occurred within one month of enrollment; 4. Agree to participate in this study and have signed the informed consent form;
Exclusion criteria
Exclusion criteria: Compensatory cirrhosis group : 1. Patients with severe extrahepatic diseases, including severe weakness of cardiopulmonary and renal function, hematological diseases, malignant tumors, etc. ; 2. now or have had complications of cirrhosis ( ascites, gastrointestinal bleeding, hepatic encephalopathy, hepatorenal syndrome, etc. ) ; 3. had participated in other clinical trials within 4 weeks before the start of this study ; 4. pregnant or lactating women ; 5. patients with organic mental illness, unable to cooperate with patients ; 6. had used antibiotics, probiotics or immunosuppressive agents within 6 weeks ; 7. Inflammatory bowel disease, acute and chronic gastrointestinal infectious diseases ; 8. with HIV, AIDS and other serious infectious diseases. Decompensated cirrhosis group : 1. previous history of hepatocellular carcinoma or other malignant tumors, severe extrahepatic diseases such as cardiopulmonary failure, etc; 2. participated in other clinical trials within 4 weeks before the start of this study; 3. pregnant or lactating women; 4. patients with organic mental illness, unable to cooperate with patients; 5. used antibiotics, probiotics or immunosuppressive agents within 6 weeks; 6. inflammatory bowel disease, acute and chronic gastrointestinal diseases; 7. HIV, AIDS and other serious infectious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decompensated complications of liver cirrhosis occur;Clinical characteristics, fecal gut microbiota, and fecal metabolite profiles;Medical history and physical examination (including vital signs, height, weight, BMI, and systemic physical examination);Laboratory tests (complete blood count, blood biochemistry, coagulation profile, etc.);Stool routine examination (fecal occult blood);Abdominal imaging examinations (CT, MRI) and endoscopy results; | — |
Countries
China
Contacts
Public ContactWang Anjiang
Shenzhen Hospital of Southern Medical Unversity
Outcome results
None listed