Skip to content

Effectiveness of a self-assembled biomacromolecular dental desensitizer on dentin hypersensitivity after non-surgical periodontal therapy: a randomized, double-blind, split-mouth controlled clinical trial

Effectiveness of a self-assembled biomacromolecular dental desensitizer on dentin hypersensitivity after non-surgical periodontal therapy: a randomized, double-blind, split-mouth controlled clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122467
Enrollment
Unknown
Registered
2026-04-14
Start date
2026-04-15
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin hypersensitivity

Interventions

test group:Apply the polymer desensitizer to the tooth surface
control group:Apply a placebo paste to the tooth surface that is identical in appearance and smell to the desensitizer but does not contain the active ingredient

Sponsors

Stomatological Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-70 years, regardless of gender; 2. Diagnosed with periodontitis (according to the 2018 new classification of periodontal diseases) and scheduled to undergo full-mouth non-surgical periodontal treatment (NSPT); 3. Presence of at least two affected teeth in different quadrants (or contralateral homonymous teeth) confirmed to have dentin hypersensitivity symptoms [VAS score >= 4 (out of a total score of 10)]; 4. The affected teeth are caries-free, crack-free, and have intact dental restorations; 5. No professional anti-sensitive treatment or periodontal surgery received in the past 3 months; 6. Agree to participate in this study, sign the informed consent form, and demonstrate good compliance.

Exclusion criteria

Exclusion criteria: 1. The affected tooth presents with acute periodontal abscess, pulpitis, or periapical lesions; 2. Presence of severe or uncontrolled systemic diseases (e.g., severe hypertension, diabetes, hepatic or renal insufficiency); 3. Long-term use of anticoagulants, analgesics, anti-inflammatory drugs, or antidepressants (which may interfere with pain perception); 4. Uncontrolled dental erosion (e.g., due to gastroesophageal reflux disease) or eating disorders (e.g., anorexia nervosa); 5. Known allergy to any component of the study material; 6. Pregnant or breastfeeding women; 7. Currently undergoing orthodontic treatment.

Design outcomes

Primary

MeasureTime frame
VAS score on cold air stimulation;

Secondary

MeasureTime frame
VAS score on tactile stimulation;Subjective sensitivity;

Countries

China

Contacts

Public ContactShao Jinlong

Stomatological Hospital of Shandong University

jinlong.shao@sdu.edu.cn+86 158 6669 8773

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026