Acute Ischemic Stroke
Conditions
Interventions
Conservative BP management group:Restrictive blood pressure management strategy: In principle, antihypertensive drugs should not be initiated within 24 hours after the operation. Only when systolic bl
Intensive antihypertensive group:Active antihypertensive strategy: Administer urapidil hydrochloride intravenously within 24 hours after the operation to steadily control systolic blood pressure at 14
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years, regardless of gender; 2. Clinically diagnosed with acute ischemic stroke, confirmed by imaging (CTA/MRA) as anterior circulation large vessel occlusion; 3. Underwent endovascular thrombectomy with successful postoperative reperfusion (modified Thrombolysis in Cerebral Infarction [mTICI] grade 2b, 2c, or 3); 4. Baseline blood pressure: mean systolic blood pressure (SBP) >140 mmHg measured after admission and prior to any antihypertensive intervention (based on three consecutive readings taken at 10-minute intervals) 5. Time from symptom onset to completion of reperfusion <=24 hours; 6. Written informed consent provided by the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Known or suspected secondary hypertension (e.g., uncontrolled pheochromocytoma or renovascular hypertension), patients with hepatic or renal failure, or those undergoing hemodialysis; 2. Blood pressure that cannot be controlled with antihypertensive medication; 3. Pregnant or breastfeeding women; 4. Pre-existing neurological or psychiatric disorders that would interfere with the assessment of neurological function; 5. Life expectancy <90 days (e.g., advanced malignancy) or inability to complete the 90-day follow-up; 6. currently participating in other clinical drug trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of functional independence at 90 days (mRS 0-2);Incidence of symptomatic intracranial hemorrhage at 72 hours;Stroke-related mortality at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS score at 72 hours and discharge;90-day EQ-5D-5L score;Infarct volume changes at 24 hours, 72 hours, and discharge;Incidence of any intracranial hemorrhage during hospitalization;Incidence of malignant cerebral edema during hospitalization;Incidence of neurological deterioration at 72 hours (END, defined as an increase in NIHSS score >=4 points); | — |
Countries
China
Contacts
Public ContactLiu Wenjie
West China Hospital, Sichuan University
Outcome results
None listed