Allergic Rhinitis
Conditions
Interventions
Children with allergic rhinitis:none
control group:none
Sponsors
Fujian Children's Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: 1. Children with allergic rhinitis: (1) Aged 5–12 years, with allergic rhinitis; (2) Serum house dust mite-specific IgE level greater than grade 3; (3) No prior history of allergen immunotherapy (AIT); (4) Meet the indications for AIT; (5) Voluntarily participate in the study and comply with the relevant assessments. 2. Control Group: (1) Age between 5-12 years; (2) No history of allergic rhinitis or any allergic diseases (such as asthma, atopic dermatitis, food/drug allergies) confirmed through detailed health inquiry and physical examination; (3) Negative results in serum allergen screening (such as dust mite-specific IgE); (4) Stable vital signs, growth and development within the normal range for children of the same age; (5) Legal guardian voluntarily signs the informed consent form, and the child is willing to cooperate with the study tests.
Exclusion criteria
Exclusion criteria: 1. Children with allergic rhinitis: (1) Use of antibiotics, prebiotics, probiotics, or synbiotics within the past month; (2) Presence of chronic gastrointestinal disorders, including inflammatory bowel disease, celiac disease, and irritable bowel syndrome; (3) Acute gastroenteritis or antibiotic-associated diarrhea within the past 4 weeks; (4) History of gastrointestinal surgery (e.g., gastrectomy, bowel resection); (5) Biliary tract diseases; (6) Coexisting allergic diseases, such as asthma or atopic dermatitis; (7) Any other serious conditions, including metabolic diseases, malignancies, autoimmune diseases, or immunodeficiencies; (8) Discontinuation of the intervention during the study period. 2. Control Group: (1) Use of antibiotics, prebiotics, probiotics, or synbiotics in the past month; (2) History of chronic gastrointestinal diseases, including inflammatory bowel disease, celiac disease, irritable bowel syndrome, etc.; (3) Acute gastroenteritis or antibiotic-associated diarrhea in the past 4 weeks; (4) History of gastrointestinal surgery (such as partial gastrectomy or intestinal resection); (5) Any serious chronic disease such as bile duct disease, metabolic disease, malignant tumor, autoimmune disease, or immunodeficiency; (6) Other conditions that the investigator judges may interfere with the evaluation of study results (such as recent acute infections) or affect the safety of the subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Nasal Symptom Score; gut microbiota;Nasopharyngeal microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| cytokines;blood eosinophil;sIgG4;tIgE; | — |
Countries
China
Contacts
Public ContactYanling Chen
Fujian Children's Hospital
Outcome results
None listed