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A Study on the Efficacy Tegileridine Fumarate Injection in Combination with Adductor Canal Block for Postoperative Analgesia afler Total Knee Arthroplasty

A Study on the Efficacy Tegileridine Fumarate Injection in Combination with Adductor Canal Block for Postoperative Analgesia afler Total Knee Arthroplasty

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122439
Enrollment
Unknown
Registered
2026-04-14
Start date
2026-04-15
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Disorders

Interventions

Group S:The patient was administered a self-controlled analgesic pump with sufentanil 135 µg and flurbiprofen lipide 450 mg. Thirty minutes prior to the end of the procedure, a loading dose of 4 mL wa
Group T:The patient was administered a patient-controlled analgesia (PCA) pump with tegilide 15mg. Thirty minutes prior to the end of the procedure, a slow infusion was initiated, followed by a loadin

Sponsors

The Eighth Affiliated Hospital, SunYat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients aged 60-75 years, ASA class I-III, with a body mass index (BMI) of 18-29.5 kg/m², and who have signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Long-term use of analgesics for chronic pain conditions; 2. History of allergy to amide local anesthetics; 3. Preoperative contraindications for nerve block; 4. Patients with severe mental or psychological disorders who cannot cooperate with treatment or those with language impairment; 5. Patients with central nervous system diseases; 6. History of acute or severe bronchial asthma.

Design outcomes

Primary

MeasureTime frame
NRS pain score (rest/activity);

Secondary

MeasureTime frame
Knee joint range of motion;quadriceps muscle strength;Pain pump data (presses, total volume);Palliative analgesia (duration, dosage);untoward effect ;Postoperative hospitalization duration;

Countries

China

Contacts

Public ContactPeng Yue

The Eighth Affiliated Hospital, SunYat-Sen University

3662624240@qq.com+86 159 8668 6015

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026