Study on the mechanism of Porphyromonas gingivalis-mediated CCL2-CCR2 signaling pathway in the malignant transformation of oral leukoplakia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2600122437

Enrollment

Unknown

Registered

2026-04-14

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucosal leukoplakia

Interventions

OLK group:None

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-75 with a pathological diagnosis of oral leukoplakia

Exclusion criteria

Exclusion criteria: 1. Those with a history of hepatitis B, tuberculosis, HIV and syphilis positive; 2. Patients with a limited life expectancy of less than one year; 3. Severe heart failure (NYHA grade =3); 4. Liver and kidney dysfunction (ALT or AST>20ULN, ALP>20ULN, BIL>10ULN) (eGFR<15ml/min/1.73m^2); 5. Patients with acute cerebral infarction within 3 months; 6. Patients with respiratory failure or severe lung diseases.

Design outcomes

Primary

Measure	Time frame
Microbial testing;P.Correlation analysis between g and OLK prognosis;P.The influence of g on the carcinogenesis of abnormally hyperplastic epithelium;The role of the CCL2/CCR2 axis in the prognosis of OLK;	—

Countries

China

Contacts

Public ContactLi Xiatian

Shanghai Xuhui District Stomatological Hospital (Shanghai Xuhui District Dental Disease Prevention and Treatment Institute)

1012452270@qq.com+86 21 64037289

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026