A Prospective Efficacy Study of Active Lung Volume Recruitment Techniques in Early Lung Volume Decline in DMD

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122429

Enrollment

Unknown

Registered

2026-04-14

Start date

2026-04-15

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Duchenne muscular dystrophy

Interventions

Intervention Group:Practice glossopharyngeal breathing at home for 20 minutes daily, with video follow-up once a week, for a continuous period of 6 months.

Control group:Outpatient follow-up will be conducted once every 3 months. Free training guidance will be provided upon completion of the study.

Eligibility

Sex/Gender

Male

Age

8 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Male children aged 8-18 years old, diagnosed with Duchenne muscular dystrophy (DMD) by genetic testing and/or muscle biopsy; 2. Possessing age-appropriate cognitive and comprehension abilities, able to actively cooperate with pulmonary function tests and complete active lung volume recruitment techniques such as glossopharyngeal breathing; 3. Pulmonary function test results: Forced Vital Capacity (FVC) = 8 years old), they shall also sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Having intellectual disabilities (IQ<70, confirmed by standardized intelligence assessment scales) or mental and psychological disorders, unable to understand and cooperate with training and assessment processes; 2. Existence of severe heart failure (New York Heart Association functional class III-IV), severe arrhythmia, or uncontrolled pulmonary infection; 3. Has undergone tracheotomy or is currently using an invasive ventilator for assisted ventilation; 4. Possess glossopharyngeal dysfunction (such as difficulty swallowing grade III or above, tongue muscle paralysis), unable to complete glossopharyngeal breathing movements; 5. Simultaneously participate in other intervention clinical trials targeting DMD respiratory function.

Design outcomes

Primary

Measure	Time frame
Spirometry;	—

Secondary

Measure	Time frame
End-tidal carbon dioxide pressure (EtCO2);PedsQL 4.0 Generic Core Scales;Anthropometric indicators;	—

Countries

China

Contacts

Public ContactXiaotang Cai

West China Second University Hospital, Sichuan University

cxt_1999@126.com+86 181 8060 9237

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026