Chemotherapy-induced myelosuppression
Conditions
Interventions
Control group:Treated in accordance with normal medical procedures
Intervention group:Risk assessment of bone marrow suppression, medication recommendations, intervention for adverse reactions, drug adjustment, treatment evaluation, patient education, etc.
Sponsors
Yuebei People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 75 years old; 2. Patients diagnosed with malignant solid tumors at stage III-IV by histopathological examination (priority will be given to tumor types with high risk of bone marrow suppression such as lung cancer and breast cancer); 3. Undergoing bone marrow suppressive chemotherapy (including platinum-based/anthracycline-based/paclitaxel-based drugs), with an expected survival period of more than 6 months; 4. Having experienced grade II or above bone marrow suppression in previous chemotherapy (according to CTCAE v6.0) or the current treatment plan is expected to carry a medium to high risk of suppression; 5. Have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previously had hematopoietic system diseases such as myelodysplastic syndrome, aplastic anemia, leukemia, etc.; 2. Patients allergic to G-CSF, TPO/TPO-RA or tralaxel; 3. Patients with tuberculosis, HIV positive, uncontrolled heart failure, renal failure or liver failure (Child-Pugh C grade) during the study period; 4. Patients with mental disorders, cognitive deficits or unable to complete follow-up; 5. Patients with concurrent radiotherapy plan during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of grade III/IV bone marrow suppression;Duration of bone marrow suppression; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of adjusting chemotherapy drug dosage;The usage rate of G-CSF/TPO/TPO-RA;Complication occurrence rate;Hospitalization period;Medical expenses;Patient quality of life assessment; | — |
Countries
China
Contacts
Public ContactHaiying Zhong
Yuebei People’s Hospital
Outcome results
None listed