The effect of preoperative night dexmedetomidine nasal spray on postoperative delirium in elderly patients undergoing hip replacement

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2600122404

Enrollment

Unknown

Registered

2026-04-13

Start date

2026-04-13

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Control group:At 20:00 the day before surgery, administer saline nasal spray, one spray in each nostril.

Research group:At 20:00 the day before surgery, administer dexmedetomidine nasal spray, one spray in each nostril.

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for their first total hip arthroplasty under general anesthesia; 2.Age >= 60 years; 3.BMI 18-28 kg/m^2; 4.Patients classified as ASA I-III by the American Society of Anesthesiologists; 5.Signed informed consent for anesthesia;

Exclusion criteria

Exclusion criteria: 1.Patients with preoperative cognitive impairment (assessed using the MMSE scale); 2.Those with a history of schizophrenia, Alzheimer's disease, Parkinson's disease, or dementia (as indicated in the recorded medical history); 3.Heart rate <=60 beats/min or other severe conduction disorders, liver dysfunction (Child-Pugh grade B or C), or kidney dysfunction (uremic stage or receiving preoperative dialysis); 4.Currently using dexmedetomidine, esketamine, or benzodiazepines; 5. Allergic to dexmedetomidine used in this study; 5.Allergic to dexmedetomidine used in this study; 6.Unable to communicate or understand the scales assessed by the investigator; 7.Refusal to sign the informed consent or inability to cooperate with the protocol;

Design outcomes

Primary

Measure	Time frame
Incidence of delirium on postoperative;	—

Secondary

Measure	Time frame
Sleep staging;Other perioperative indicators;Athens Insomnia Scale (AIS);Effective pressing times of the analgesic pump, number of rescue analgesia instances;Quality of Recovery-15;Postoperative resting and movement NRS scores;10-item Telephone Interview of Cognitive Status;Pittsburgh Sleep Quality Index (PSQI);	—

Countries

China

Contacts

Public ContactWen Chao

The First Affiliated Hospital of Dalian Medical University

doctwen@163.com+86 18098876177

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026