Labor Pain
Conditions
Interventions
Group A:0.1% ropivacaine + 0.5 µg/ml dexmedetomidine
Group B:0.1% ropivacaine + 0.5 µg/ml sufentanil
Group C:0.1% ropivacaine
Sponsors
Shenzhen Luohu Maternal and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women aged 18-40 years with full-term pregnancy (>=37 weeks of gestational age), single fetus in cephalic position; 2. Planned for vaginal delivery after obstetric assessment; 3. American Society of Anesthesiologists (ASA) physical status class II; 4. Cervical dilation between 2 and 5 cm on admission, and voluntarily requested epidural labor analgesia; 5. No severe dysfunction of vital organs such as heart, lung, liver, and kidney; 6. No severe endocrine diseases, organic neurological diseases, or psychiatric diseases; 7. Physical condition assessed by anesthesiologists to be tolerable to the labor process and epidural anesthesia; 8. No contraindications to epidural/intrathecal anesthesia (e.g., spinal deformity, infection at puncture site, coagulation dysfunction, etc.); 9. No history of allergy to ropivacaine, dexmedetomidine, or other study-related medications; 10. The parturient and her family have fully understood the purpose, methods, risks, and benefits of the study and have voluntarily signed the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Multiple pregnancies, preterm birth (gestational age 35 kg/m², assessed as extremely difficult to perform epidural puncture and unable to guarantee success rate; 10. History of allergy to ropivacaine, dexmedetomidine, or other amide local anesthetics; 11. Use of opioid analgesics, sedative-hypnotics, or psychotropic drugs within 48 hours before enrollment; 12. History of opioid addiction, chronic alcoholism, or participation in other drug clinical trials; 13. The parturient or her family refuses to sign the informed consent form, or voluntarily withdraws from the study midway; 14. Abnormal mental or cognitive function, unable to understand the study process, cooperate with analgesic effect evaluation and postoperative follow-up; 15. Unable to complete the observation period specified in the study due to personal reasons, or at high risk of loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset time of analgesia;NRS pain score during labor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of Motor Blockade;onsumption of analgesic drugs;Maternal delivery-related outcomes;Adverse reactions for mothers and infants; | — |
Countries
China
Contacts
Public ContactZhang Yuan
Shenzhen Luohu Maternal and Child Health Care Hospital
Outcome results
None listed