Polycystic ovary syndrome
Conditions
Interventions
TRE group:The subjects underwent a 12-week TRE intervention and completed a 12-week follow-up period.
HIIT group:The subjects underwent a 12-week HIIT intervention and completed a 12-week follow-up period.
MET group:The subjects underwent a 12-week MET intervention and completed a 12-week follow-up period.
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 40 years old; 2. Meets the diagnostic criteria for Rotterdam Polycystic Ovary Syndrome; 3. BMI >= 25 kg/m^2; 4. HOMA-IR >= 2.5; 5. Weight stability (weight fluctuation < 5% in the 3 months prior to enrollment, based on at least 2 objective measurements spaced 4 weeks apart); 6. Voluntary and able to strictly follow the intervention protocol specified in the study.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with diabetes; 2. Has other endocrine diseases besides polycystic ovary syndrome (such as congenital adrenal hyperplasia, Cushing's syndrome, aldosterone excess syndrome, androgen-secreting tumors, hyperprolactinemia, thyroid diseases, premature ovarian failure, etc.) and is undergoing treatment but the condition is not under control; 3. Has taken oral contraceptives, non-luteinizing hormone-releasing hormone drugs, insulin sensitizers (metformin, pioglitazone), drugs affecting weight (such as orlistat, glucocorticoids, etc.) or drugs affecting appetite and gastrointestinal motility within the past 3 months; 4. Has severe liver function impairment (ALT >= 3ULN); renal insufficiency (eGFR = 4 days per week) by the investigator; 18. Has musculoskeletal system diseases or injuries that affect exercise ability (including but not limited to acute and chronic arthritis, osteoarthritis, severe joint pain, recent fractures, tendon/ligament injuries, etc.); 19. Patients whose exercise is prone to induce breathing difficulties; 20. Family history of early-onset unexplained sudden death or known hereditary cardiovascular diseases leading to sudden death; 21. Within the past 3 months, has had an average of >= 150 minutes of high-intensity physical activity per week, assessed by the International Physical Activity Questionnaire (IPAQ); 22. By the investigator's judgment, has other serious systemic diseases or other reasons that make them unsuitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin resistance index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;Body fat distribution;Metabolic risk factors;Sex hormones;Menstrual cycle;Quality of life; | — |
Countries
China
Contacts
Public ContactZhang Haohao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed