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Research on the Role and Mechanism of TRPM8 in Chronic Heart Failure

Research on the Role and Mechanism of TRPM8 in Chronic Heart Failure

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600122391
Enrollment
Unknown
Registered
2026-04-13
Start date
2026-04-13
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic cardiomyopathy

Interventions

Healthy control group:None
Heart failure case group:None

Sponsors

Shandong Provincial Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age >18 years old, male or female; 2. Previous history of myocardial infarction confirmed by coronary angiography and blood myocardial infarction; 3. the history of myocardial infarction >3 months without acute myocardial infarction in the past 3 months; 4. Left ventricular ejection fraction (LVEF) <=50%, New York Heart Association (NYHA) class < 4; 1.Age, gender and other general clinical information were not significantly different from those of patients with heart failure.

Exclusion criteria

Exclusion criteria: 1. Congenital heart disease, acute myocardial infarction, valvular heart disease, constrictive pericarditis; 2. Chronic obstructive pulmonary disease, thyroid disease; 3. Uncontrolled hypertension and malignant arrhythmia; 4. Severe liver and kidney dysfunction, immune system, mental disorders, tumor and other serious diseases can not tolerate recipients; 5. Pregnancy/lactation.

Design outcomes

Primary

MeasureTime frame
TRPM8 mRNA;

Secondary

MeasureTime frame
Markers of inflammation;

Countries

China

Contacts

Public ContactGao Dongxue

Shandong Provincial Third Hospital

yxgaodongxue@126.com+86 531 81656202

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026