depressive disorder
Conditions
Interventions
Control Group:Healthy individuals.:none
High-frequency rTMS stimulation of the left dorsolateral prefrontal cortex group:repetitive transcranial magnetic stimulation
High-frequency sham stimulation of the left dorsolateral prefrontal cortex group:High-frequency sham stimulation
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patient Group: 1. Age 18-60 years (inclusive), roughly balanced gender ratio; 2. Meet the diagnostic criteria for depression in the DSM-V (confirmed by MINI questionnaire); 3. First-episode or recurrent patients who have not received related antidepressants, antipsychotics, or mood stabilizers within 2 weeks of baseline screening; 4. Chinese Han population, both sides of three generations of direct relatives are Han; 5. Education level of elementary school or above (years of education =6) able to understand the scale content; 6. Depressed patients meeting baseline Hamilton Depression Rating Scale 17-item (HAMD-17) score =14; Montgomery-Åsberg Depression Rating Scale (MADRS) score =12; 7. Willing to take contraceptive measures during the study and within 2 months after the study; 8. Fully understand the safety of rTMS, willing to actively cooperate with treatment, and sign informed consent. Normal Control Group: Matched by age, years of education, and gender according to the number of patients enrolled, not meeting the exclusion criteria, with 60 participants included.
Exclusion criteria
Exclusion criteria: Patient Group: 1. Currently participating in other medical research projects, or completed other medical research projects but the residual effects cannot exclude the impact on this study; 2. Assessed by a physician to currently have a high risk of suicide or aggression, HAMD-17 item 3 score =2 or Beck Scale for Suicide Ideation-Chinese Version (BSI-CV) score =6; 3. Currently have severe physical illness deemed by the researcher as unsuitable for inclusion; 4. Currently have contraindications for MRI, such as newly implanted cardiac stent, metal dentures, etc.; 5. IQ <70 or suspected intellectual developmental delay; 6. History of substance abuse or dependence (excluding nicotine and caffeine but including alcohol) or positive urine test for prohibited drugs during screening. Normal Control Group: 1. Current or past history of mental illness, or abnormal mental illness history in two-lineage three generations; 2. Current or past history of neurological disease, autoimmune disease, or severe physical disease; 3. Current or past history of substance abuse or dependence; 4. Contraindications for MRI, such as cardiac stent, pacemaker, metal dentures, etc.; 5. Female participants who are pregnant or breastfeeding; 6. Estimated poor compliance or inability to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The reduction rate of the Snaith-Hamilton Pleasure Scale (SHAPS);Hamilton depression Scale reduction rate;Cranial magnetic resonance data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton anxiety Scale reduction rate; | — |
Countries
China
Contacts
Public ContactShen zonglin
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed