overweight or obesity
Conditions
Interventions
Orlistat group:none
Liraglutide group:none
Beinaglutide group:none
Tilporopeptide group:none
Mazdutide group:none
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18 years; 2.Obesity (BMI = 28 kg·m-2) or overweight (BMI = 24.0 - 27.9 kg·m-2) and having at least one weight-related complication (such as prediabetes, hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, metabolic associated fatty liver disease, or weight-bearing joint pain); 3.Having a history of one or more failed attempts at weight loss through dieting.
Exclusion criteria
Exclusion criteria: 1.Diabetes, 2.A weight change of more than 5 kilograms (or 5%) within 90 days before enrollment, 3.Treatment with weight loss-promoting drugs within 90 days before enrollment, 4.Women who are pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of weight reduction from the baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of weight reduction from the baseline;Absolute weight reduction from the baseline;BMI;Waist circumference;Blood pressure;Total cholesterol;LDL-C;HDL-C;TG;Heart rate;Fasting blood glucose;HbA1C;Fasting insulin;Fasting C-peptide;HOMA-IR;Depressed mood or depression;Anxiety disorder;Irritability;Sleep disorder;Suicide; | — |
Countries
China
Contacts
Public ContactTiantian Gao
Shangong Provincial Hospital
Outcome results
None listed