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A comparison of the efficacy of pre-incision endoscopic mucosal resection versus endoscopic submucosal dissection for the treatment of large, flat colorectal lesions (2-3 cm): a multicenter prospective randomized controlled non-inferiority study.

A comparison of the efficacy of pre-incision endoscopic mucosal resection versus endoscopic submucosal dissection for the treatment of large, flat colorectal lesions (2-3 cm): a multicenter prospective randomized controlled non-inferiority study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600122370
Enrollment
Unknown
Registered
2026-04-13
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Flat colorectal lesions require endoscopic treatment.

Interventions

ESD group:Patients undergoing ESD treatment for colorectal lesions
EMR-P group:Endoscopic resection followed by EMR for colorectal lesions

Sponsors

The First Affiliated Hospital of Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients with flat colorectal lesions (2-3 cm) deemed resectable by physicians, within guideline indications, and eligible for ESD or EMR-P treatment; 2. Signed informed consent; 3. Aged 18 years or older.

Exclusion criteria

Exclusion criteria: 1. Patients with severe coagulation disorders; 2. Patients with serious underlying diseases who cannot tolerate endoscopic surgery.

Design outcomes

Primary

MeasureTime frame
Postoperative lesion R0 resection rate;

Secondary

MeasureTime frame
Economic benefits;The incidence of adverse events includes delayed bleeding, delayed perforation, etc.;Operation time of surgery;

Countries

China

Contacts

Public ContactLu Chao

The First Affiliated Hospital of Zhejiang University School of Medicine

chaolu0213@zju.edu.cn+86 571 87236861

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026