Helicobacter pylori infection?
Conditions
Interventions
Group VAMB:Vonoprazan + Amoxicillin+Minocycline+bismuth
Group VM:Vonoprazan + Minocycline
Sponsors
People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Department of Gastroenterology
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients aged 18–70 years;?? 2.Patients with newly diagnosed active Helicobacter pylori(Hp) infection confirmed by either ¹4C-urea breath test (UBT) or histopathological examination;?**? 3.Patients who have not taken potassium-competitive acid blockers (P-CABs), proton pump inhibitors (PPIs), H2-receptor antagonists, hydrotalcite, bismuth preparations, sucralfate, or misoprostol within the past 2 weeks;?? 4.Patients who have not received antibiotics or antibacterial traditional Chinese medicines (e.g., Jinghua Weikang, Moro Dan, berberine) within the past 4 weeks.?
Exclusion criteria
Exclusion criteria: 1. Patients who are intolerant to or allergic to any drug in the study; 2. Female patients who are pregnant, breastfeeding, or planning pregnancy; 3. Recent history of gastrointestinal haemorrhage, obstruction, perforation, tumours, or other serious organic diseases; 4. Patients with severe cardiac, hepatic, or renal insufficiency, or compromised immunity; 5. Patients with psychiatric disorders, psychological impairments, or inability to cooperate with research personnel. 6. Lack of informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event;Compliance; | — |
Countries
China
Contacts
Public ContactSheng juan,Hu
People's Hospital of Ningxia Hui Autonomous Region, Ningxia Medical University, Department of Gastroenterology
Outcome results
None listed