Moderate to mild depression, moderate to mild anxiety
Conditions
Interventions
Control Group:placebo
Experimental Group:Happy Season Probiotic Powder
Sponsors
Wuxi No.2 People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-70 years old; 2.The Self-Rating Anxiety Scale (SAS) score is 50-69 points (mild to moderate anxiety), and the Self-Rating Depression Scale (SDS) score is 53-62 points (mild to moderate depression). 3.Have not taken probiotic preparations, anti-anxiety/antidepressant drugs, or sedative-hypnotic drugs in the past month; have not used antibiotics, glucocorticoids, or other drugs that affect intestinal flora in the past 2 weeks; have a regular daily diet, and have no habit of long-term consumption of fermented foods (yoghurt, kimchi, natto, etc.); 4.He reported no gastrointestinal ulcers, inflammatory bowel disease, low immune function and other diseases; no history of serious mental illness such as schizophrenia and bipolar disorder; no chronic underlying diseases such as liver and kidney insufficiency, cardiovascular and cerebrovascular diseases. 5.Voluntarily sign the informed consent form, understand and commit to abide by all research procedures (including taking trial products on time, completing interviews, recording logs, etc.);
Exclusion criteria
Exclusion criteria: 1.People allergic to probiotic strains and placebo ingredients; 2.Women who are pregnant, lactating, or planning to become pregnant during the trial; 3.Those who have participated in other clinical trials in the past 3 months, or are receiving psychotherapy or cognitive behavioral intervention; 4.Those with a history of alcohol, tobacco or drug dependence, or long-term drinking of strong tea and coffee (=3 cups a day); 5.Those who are unable to cooperate in completing the questionnaire, recording medication, or cannot be contacted during the follow-up period;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive state;anxious state; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine test, liver and kidney function tests; | — |
Countries
China
Contacts
Public ContactCao pei
Wuxi No.2 People’s Hospital
Outcome results
None listed